Key result
Loaded shortening of single frog muscle fibres depressed tetanic force by 13 +/- 2%, which was positively correlated with the non-uniformity of sarcomere length along the fibre (P<0.005).
Absolute Event Rate: 13% vs 0%
p-value: p=<0.005
Force depression after loaded shortening of a single muscle fibre is attributable to non-uniform sarcomere behaviour along the fibre, supporting the view that myosin cross-bridges act as independent force generators.
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May implicate sarcomere non-uniformity in force depression; leaves open relevance to cardiac muscle in vivo.
Edman et al. (1993) studied this question. Loaded shortening during a fused tetanus vs. Fixed-end tetanus at the same overall fibre length or unloaded shortening was evaluated on Tetanic force depression (p=<0.005). Loaded shortening of single frog muscle fibres depressed tetanic force by 13 +/- 2%, which was positively correlated with the non-uniformity of sarcomere length along the fibre (P<0.005).
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