Why the study?
Does the metabolic handling of apoA-I and apoA-II differ between healthy males and females to explain differences in HDL subfraction distribution?
Population
10 healthy age-matched volunteers (5 males, 5 females)
Comparison
Examination of the metabolism of major HDL… vs Males versus females
Design
Cross-sectional
Authors
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ApoA-I/II kinetics do not explain female HDL2 predominance; hypothesis-generating for other mechanisms.
Does the metabolic handling of apoA-I and apoA-II differ between healthy males and females to explain differences in HDL subfraction distribution?
The increased HDL2:HDL3 ratio observed in females compared to males is not driven by measurable differences in the metabolic handling of apoA-I or apoA-II.
Shepherd et al. (1978) studied this question.
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