Does the metabolic handling of apoA-I and apoA-II differ between healthy males and females to explain differences in HDL subfraction distribution?
The increased HDL2:HDL3 ratio observed in females compared to males is not driven by measurable differences in the metabolic handling of apoA-I or apoA-II.
Rate zonal ultracentrifugation of plasma samples from ten healthy age-matched volunteers (five males, five females) indicated that the high density lipoprotein subfraction ratio (HDL2:HDL3) in females was significantly higher than in males. The cause of this phenomenon was investigated by simultaneous examination of the metabolism of the major HDL apoproteins (apoA-I and apoA-II) in both groups. The results show that there is no significant sex-related difference in the plasma pool size, fractional catabolic rate, or synthetic rate of either apoprotein. We conclude that the increased HDL2:HDL3 ratio in femalse versus males does not derive from measurable differences in the metabolic handling of either apoprotein.
Shepherd et al. (Thu,) studied this question.
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