Key result
Mean platelet volume was significantly higher in obese adolescents and maintained a positive, independent association with left common carotid artery thickness (P=0.002).
Why the study?
Is mean platelet volume correlated with carotid intima media thickness in obese adolescents?
Case-Control (n=91)
Is mean platelet volume correlated with carotid intima media thickness in obese adolescents?
Mean platelet volume is independently correlated with carotid intima media thickness in obese adolescents, suggesting it may serve as a marker for early subclinical atherosclerosis.
MPV may mark early vascular changes in obese adolescents; hypothesis-generating and requires prospective validation before clinical adoption.
AIMS: This study aims to assess the correlation of mean platelet volume (MPV) and common carotid artery (CCA) thickness in a population of obese adolescents. METHODS: Sixty-eight patients and 23 controls were enrolled. Anthropometric measurements, triglyceride, total cholesterol, high-density lipoprotein cholesterol, low-density lipoprotein cholesterol, alanine aminotransferase, aspartate aminotransferase, γ-glutamyl transpeptidase, hemoglobin, white blood cell count, platelet count, MPV and insulin resistance by homeostasis model of assessment of insulin resistance were investigated. Furthermore, CCA thickness was measured by high-resolution ultrasound. RESULTS: MPV and the left CCA thickness were significantly higher in obese adolescents than the healthy controls. The association between MPV and left CCA was checked by linear regression analysis. MPV explained 19% of the variation in left CCA (P < 0.001). At multiple regression analysis, MPV maintained a positive association with the left CCA thickness (P = 0.002) independently of fatty liver grade, relative weight, total cholesterol and homeostasis model of assessment of insulin resistance. CONCLUSION: MPV is significantly correlated with CCA thickness in obese adolescents.
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Arslan et al. (2013) conducted a case-control in Obesity (n=91). Obesity vs. Healthy controls was evaluated on Correlation between mean platelet volume (MPV) and left common carotid artery (CCA) thickness (19% of variation explained, p=<0.001). Mean platelet volume was significantly higher in obese adolescents and maintained a positive, independent association with left common carotid artery thickness (P=0.002).
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