Key result
In the absence of other metabolic risk factors, non-alcoholic fatty liver disease was not associated with significant differences in mean platelet volume (8.9 vs 8.8 fL, p=0.77) or carotid intima-media thickness compared to healthy controls.
Why the study?
Are mean platelet volume (MPV) and carotid artery intima media thickness (CIMT) increased in patients with NAFLD without other metabolic risk factors compared to healthy controls?
Case-Control (n=114)
Single-blind
No
Are mean platelet volume (MPV) and carotid artery intima media thickness (CIMT) increased in patients with NAFLD without other metabolic risk factors compared to healthy controls?
Absolute Event Rate: 8.9% vs 8.8%
p-value: p=0.77
In the absence of other metabolic risk factors, mean platelet volume is not elevated in NAFLD and does not correlate with subclinical atherosclerosis as measured by CIMT.
Does not support MPV or CIMT assessment in isolated NAFLD; leaves open whether metabolic comorbidities drive any vascular associations.
BACKGROUND: Non-alcoholic fatty liver disease (NAFLD) is linked to an increased risk of cardiovascular disease. Mean platelet volume (MPV), a determinant of platelet activation, is an emerging risk factor for atherothrombosis. AIMS: The aim of this study was to investigate the levels of MPV in subjects with NAFLD having no confounding factors for atherosclerosis such as obesity, diabetes mellitus, and hypertension. In addition, the possible relationship between MPV and carotid artery intima media thickness (CIMT), a well known marker of subclinical atherosclerosis, was also studied. METHODS: MPV and CIMT levels were measured in 60 biopsy-proven NAFLD subjects and 54 healthy controls. Age and sex were similar between two groups. RESULTS: Body mass index and waist circumference levels were higher in the NAFLD group when compared to the controls. There were no differences between the two groups regarding LDL cholesterol levels, whereas HDL cholesterol levels were lower in the NAFLD group. MPV and CIMT levels were not different between the two groups. According to the correlation analyses, CIMT levels were positively correlated to age in patients with NAFLD. However, no significant correlation was found between MPV and CIMT levels. CONCLUSIONS: The results of this study do not show any difference in MPV levels between subjects with NAFLD and controls. These finding suggests that in the absence of other metabolic risk factors, MPV might not be involved in the mechanism(s) of increased cardiovascular risk in NAFLD.
No takes yet. Share an insight, caveat, or question.
Kılcıler et al. (2010) conducted a case-control in Non-alcoholic fatty liver disease (NAFLD) (n=114). Non-alcoholic fatty liver disease (NAFLD) vs. Healthy controls was evaluated on Mean platelet volume (MPV) (p=0.77). In the absence of other metabolic risk factors, non-alcoholic fatty liver disease was not associated with significant differences in mean platelet volume (8.9 vs 8.8 fL, p=0.77) or carotid intima-media thickness compared to healthy controls.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: