Key result
Mean platelet volume was not significantly different between patients with and without hepatic steatosis and did not predict NAFLD (P > 0.05).
Why the study?
While the relationship of mean platelet volume with inflammatory diseases is known, its role in nonalcoholic fatty liver disease without cardiovascular comorbidities, obesity, and diabetes mellitus remains unclear.
Is mean platelet volume associated with nonalcoholic fatty liver disease in patients without cardiovascular comorbidities, obesity, and diabetes mellitus?
Observational (n=249)
Is mean platelet volume associated with nonalcoholic fatty liver disease in patients without cardiovascular comorbidities, obesity, and diabetes mellitus?
p-value: p=>0.05
Mean platelet volume is not a useful parameter to detect NAFLD in patients without cardiovascular comorbidities, obesity, and diabetes mellitus.
MPV lacks utility for NAFLD detection in nonobese, nondiabetic patients without cardiac disease; leaves open its value in other populations.
BACKGROUND: While the relation of mean platelet volume (MPV) with inflammatory diseases is obvious, its role in nonalcoholic fatty liver disease (NAFLD) without cardiovascular comorbidities, obesity and diabetes mellitus is not clear. METHODS: A total of 249 patients (nonobese, nondiabetic and not having cardiac diseases) who underwent an abdominal ultrasonography assessment were enrolled. They were divided according to the absence (group 1) or presence (group 2) of hepatic steatosis. The patients with steatosis were further divided according to the severity of steatosis as group 2a (grade 1), 2b (grade 2) and 2c (grade 3). The demographic and laboratory features were compared between groups. RESULTS: Hepatic steatosis was absent in 120 patients and detected in 129 patients (grade 1, 2, 3 hepatic steatosis in 75, 49 and 5 patients, respectively). BMI, aspartate aminotransferase/alanine aminotransferase (AST/ALT) ratio and serum AST, ALT, triglyceride levels were significantly higher in group 2 than in group 1 (P < 0.001, P < 0.001, P < 0.001, P = 0.005, P < 0.001, respectively). BMI, serum AST and triglyceride levels were significant factors for NAFLD (P < 0.001, P = 0.018, P = 0.001). MPV was neither different between groups (P > 0.05) nor a predictor factor for NAFLD (P > 0.05). CONCLUSION: MPV is a useless parameter to detect NAFLD without cardiovascular comorbidities, obesity and diabetes mellitus.
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Tüzer et al. (2021) conducted an observational in Nonalcoholic fatty liver disease (NAFLD) (n=249). Mean platelet volume (MPV) was evaluated on Presence of NAFLD / hepatic steatosis (p=>0.05). Mean platelet volume was not significantly different between patients with and without hepatic steatosis and did not predict NAFLD (P > 0.05).
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