Key result
Nonalcoholic fatty liver disease was associated with a significantly higher mean platelet volume compared to controls (random effects SMD 0.612; 95% CI 0.286-0.938; P<0.001).
Why the study?
Is nonalcoholic fatty liver disease (NAFLD) associated with increased mean platelet volume (MPV) compared to subjects without NAFLD?
Meta-Analysis (n=1,428)
Is nonalcoholic fatty liver disease (NAFLD) associated with increased mean platelet volume (MPV) compared to subjects without NAFLD?
Standardized Mean Difference: 0.612 (95% CI 0.286–0.938)
p-value: p=<0.001
Patients with NAFLD have significantly higher mean platelet volume, indicating increased platelet activity which may contribute to their elevated cardiovascular risk.
May link NAFLD to CV risk via platelet activation; leaves open causal role and outcome trials.
BACKGROUND: Nonalcoholic fatty liver disease (NAFLD) is linked to obesity, metabolic syndrome, and cardiovascular disease. Increased mean platelet volume (MPV), a marker of platelet activity, is associated with acute myocardial infarction, stroke, thrombosis, and increased mortality after myocardial infarction. The purpose of this study was to perform a meta-analysis to investigate the relationship between NAFLD and MPV. METHODOLOGY: A systematic search of MEDLINE (Ovid), PubMed, and CINAHL databases from 1950 to May 2014, complemented with manual review of references of published articles for studies comparing MPV in patients with and without NAFLD was done. Results were pooled using both fixed and random effects model. RESULTS: Our analysis from pooling of data from 8 observational studies including 1428 subjects (NAFLD=842 and non-NAFLD=586) showed that MPV was significantly higher in patients with NAFLD than those without. The standardized mean difference in MPV between NAFLD and controls was 0.457 (95% confidence interval: 0.348-0.565, P<0.001) using fixed and 0.612 (95% confidence interval: 0.286-0.938, P<0.001) using random effects model. CONCLUSIONS: This study suggests that MPV is significantly higher in patients with NAFLD, indicating the presence of increased platelet activity in such patients. Future research is needed to investigate whether this increased MPV is associated with increased cardiovascular disease in patients with NAFLD.
No takes yet. Share an insight, caveat, or question.
Madan et al. (2015) conducted a meta-analysis in Nonalcoholic fatty liver disease (n=1,428). Nonalcoholic fatty liver disease vs. Without nonalcoholic fatty liver disease was evaluated on Mean platelet volume (SMD 0.612, 95% CI 0.286-0.938, p=<0.001). Nonalcoholic fatty liver disease was associated with a significantly higher mean platelet volume compared to controls (random effects SMD 0.612; 95% CI 0.286-0.938; P<0.001).
Synapse has enriched 4 closely related papers on similar clinical questions. Consider them for comparative context: