Key result
Non-alcoholic fatty liver disease was an independent predictor of higher mean platelet volume (OR 21.98; 95% CI 2.404-201.048; p=0.006).
Why the study?
Does non-alcoholic fatty liver disease increase mean platelet volume compared to patients without fatty liver disease?
Population
Patients with non-alcoholic fatty liver disease (NAFLD) and control cases without fatty liver disease
Comparison
Non-alcoholic fatty liver disease (NAFLD) vs Patients without fatty liver disease
Design
Case-control
Authors
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NAFLD may link to platelet activation; hypothesis-generating for CVD risk and needs prospective validation before any practice change.
Observational
Does non-alcoholic fatty liver disease increase mean platelet volume compared to patients without fatty liver disease?
Odds Ratio: 21.98 (95% CI 2.404–201.048)
Absolute Event Rate: 10.43% vs 9.09%
p-value: p=0.006
Patients with NAFLD have significantly higher mean platelet volume, suggesting increased platelet activation which may indicate an elevated cardiovascular disease risk.
Özhan et al. (2009) conducted an observational in Non-alcoholic fatty liver disease (NAFLD). Non-alcoholic fatty liver disease (NAFLD) vs. Patients without fatty liver disease was evaluated on Mean platelet volume (MPV) (OR 21.98, 95% CI 2.404-201.048, p=0.006). Non-alcoholic fatty liver disease was an independent predictor of higher mean platelet volume (OR 21.98; 95% CI 2.404-201.048; p=0.006).
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