Key result
Moderate diet-induced hyperhomocysteinemia (plasma levels 3- to 4-fold higher than control) significantly exacerbated neointima formation after balloon injury in rats.
Why the study?
Does diet-induced hyperhomocysteinemia exacerbate neointima formation in rat carotid arteries after balloon injury?
Does diet-induced hyperhomocysteinemia exacerbate neointima formation in rat carotid arteries after balloon injury?
In a rat model, moderate hyperhomocysteinemia exacerbates neointima formation after balloon injury, an effect that can be mitigated by folate supplementation.
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Hyperhomocysteinemia may promote neointimal hyperplasia after vascular injury; leaves open translation to human restenosis risk.
Morita et al. (2001) studied Neointima formation after balloon injury. Diet-induced hyperhomocysteinemia vs. Control was evaluated on Neointima formation. Moderate diet-induced hyperhomocysteinemia (plasma levels 3- to 4-fold higher than control) significantly exacerbated neointima formation after balloon injury in rats.
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