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June 7, 2026ACS Applied Polymer Materials

A Multistage Surface Photografting Strategy To Functionalize Polylactic Acid with Osteogenic, Antioxidant, and Antibacterial Properties

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Authors

HZHaoqi ZhaiXHXJ HuangJLJun Liu

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Overview

Randomized trial demonstrates multifunctional polylactic acid's effectiveness in bone repair, indicating promising biomaterial applications.

Key Points

  • This research aims to develop a multifunctional polylactic acid biomaterial that combines osteogenic, antioxidant, and antibacterial properties for bone defect treatment.
  • A multistage surface photografting strategy was developed on a thiol-rich PLA substrate.
  • The osteogenic film was fabricated using methacryloyl gelatin and alendronate.
  • Further photografting created a hydrogel film with α-poly-l-lysine and tannic acid.
  • The GAn film significantly enhanced MC3T3-E1 cell proliferation with improved alkaline phosphatase activity (p<0.05).
  • The Gelm film exhibited robust antibacterial and antioxidant activity in vitro.
  • The hydrogels showed gradual degradation in collagenase environment, supporting tissue integration.

Cite This Study

Zhai et al. (2026) studied this question.

synapsesocial.com/papers/6a250a3c7def13d035e1a809https://doi.org/10.1021/acsapm.6c01221
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Evaluating Osteogenic Cell Differentiation Efficacy in the Presence of Polylactide Samples with Varied Compositions for Bone Grafting: In Vitro Study2024 · 3 citations
  2. 2Three‐Dimensional‐Printed Polylactic Acid Scaffolds Coated With a Paeonol‐Incorporated Gelatin/Bioactive Glass Composite Layer for Enhanced Osteogenic Performance2026
  3. 3Extracellular Matrix-InspiredElectrospun Nanofiber-Coated3D-Printed Polylactic Acid Scaffolds for Bone Regeneration2026
  4. 4Biointerface engineering through amalgamation of gene technology and site‐specific growth factor conjugation for efficient osteodifferentiation2024
  5. 5Bioactive PLA Filament with Antibacterial and Ion-Releasing Properties for Additive Manufacturing of Bone Scaffolds: QbD-Guided Development2026