What question did this study set out to answer?

The study aims to investigate the combined effects of sleep quality and depressive symptoms on the risk of developing digestive diseases.

June 7, 2026Scientific ReportsOpen Access

Joint associations of sleep quality and depressive symptoms with incident digestive disease in a nationally representative Chinese cohort

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Randomized trial shows how sleep quality and depressive symptoms increase digestive disease risk in adults, indicating health importance.

The study aims to investigate the combined effects of sleep quality and depressive symptoms on the risk of developing digestive diseases.
Analyzed data from 3,711 Chinese adults free of digestive disease at baseline from a national cohort study.
Assessed sleep quality using questionnaire items and depressive symptoms through CESD-10 scale.
Used Cox proportional hazards models to estimate associations with incident digestive disease, and performed exploratory mediation analyses.
Poor sleep quality increased the risk of digestive disease (HR = 1.67, 95% CI 1.39–2.01).
Depressive symptoms were associated with a higher risk (HR = 1.33, 95% CI 1.13–1.57).
Poor SQ with depressive symptoms elevated the risk further (HR = 1.80, 95% CI 1.45–2.23).

Ke et al. (2026) studied this question.

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