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August 16, 2026MedicineOpen Access

Associations of sleep duration variability and depressive symptoms with gastrointestinal disease among middle-aged and older adults

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Authors

JZJianhao ZhengNingbo No. 2 HospitalLQLing-yan QiuNingbo No. 2 HospitalDSDing ShiNingbo No. 2 Hospital

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Overview

Longitudinal cohort study demonstrates increased gastrointestinal disease risk from high sleep duration variability in older adults, indicating depressive symptoms partially mediate this link.

Key Points

  • To examine the association between sleep duration variability and gastrointestinal disease risk, and evaluate the mediating role of depressive symptoms.
  • Analyzed longitudinal data from 5,570 participants in the China Health and Retirement Longitudinal Study (CHARLS) and 2,539 participants in the Health and Retirement Study (HRS).
  • Evaluated associations using quartile grouping, subgroup analyses, sensitivity analyses, and restricted cubic spline modeling.
  • Assessed the mediating influence of depressive symptoms using a mediation effect model.
  • Gastrointestinal disease developed in 490 of 5,570 participants (8.80%) in CHARLS and 274 of 2,539 participants (10.79%) in HRS.
  • Participants in the highest quartile of sleep duration variability had significantly higher odds of gastrointestinal disease (CHARLS: OR = 1.43; HRS: OR = 1.84).
  • Restricted cubic spline curves indicated a linear increase in gastrointestinal disease risk as sleep variability increased, with depressive symptoms partially mediating this relationship.

Cite This Study

Zheng et al. (2026) studied this question.

synapsesocial.com/papers/6a817a60f2fb91fc834ae20fhttps://doi.org/10.1097/md.0000000000050280
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Also Consider

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  1. 1Association between gastrointestinal diseases and depression severity among middle-aged and older Chinese women: the mediating effect of sleep duration2026
  2. 2The association between nighttime sleep duration and digestive diseases in middle-aged and older population in China: mediating role of depression2026
  3. 3Association between gastrointestinal disorders and sleep-related problems: the mediating effect of depression2025
  4. 4Association Between Digestive Diseases, Nighttime Sleep, and Depressive Symptoms Among the Middle‐Aged and Elderly Adults: A Mediation Analysis2025
  5. 5Joint associations of sleep quality and depressive symptoms with incident digestive disease in a nationally representative Chinese cohort2026