Key result
Higher depression scores linked to ~11% greater gastrointestinal disease risk per interquartile-range increase.
Why the study?
Gastrointestinal diseases and depression represent significant public health burdens among middle-aged and older women, but their association and potential mediation by sleep duration required investigation.
Is depression severity associated with gastrointestinal diseases in middle-aged and older Chinese women, and does sleep duration mediate this relationship?
Population
6,433 women aged ≥ 45 from the CHARLS database
Comparison
Depression severity and gastrointestinal diseases
Design
Cross-sectional analysis
Authors
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Supports integrated depression-GI assessment in older women; hypothesis-generating for sleep mediation pending longitudinal data.
Cross-Sectional (n=6,433)
Is depression severity associated with gastrointestinal diseases in middle-aged and older Chinese women, and does sleep duration mediate this relationship?
Odds Ratio: 1.11 (95% CI 1.09–1.13)
p-value: p=<0.001
Liu et al. (2026) conducted a cross-sectional in Gastrointestinal diseases and depression (n=6,433). Depression severity vs. Lower depression scores was evaluated on Gastrointestinal diseases (OR 1.11, 95% CI 1.09-1.13, p=<0.001). Each interquartile-range increase in depression score was associated with an 11% higher risk of gastrointestinal diseases (OR 1.11; 95% CI 1.09-1.13; P<0.001).
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