Key result
Cancer cells can use lipoprotein lipase and CD36 to acquire preformed fatty acids from circulating lipoproteins to fuel their growth, as supported by expression in 181 tumor tissues.
Why the study?
It was hypothesized that cancer cells, in addition to de novo synthesis, may obtain preformed, diet-derived fatty acids by uptake from the bloodstream via lipoprotein lipase and CD36.
Cancer cells can utilize lipoprotein lipase and CD36 to acquire preformed fatty acids from the circulation to fuel their growth, suggesting a potential therapeutic target.
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Suggests LPL/CD36 as targets to limit tumor fatty acid supply; hypothesis-generating in animal models and leaves open clinical translation.
Kuemmerle et al. (2023) studied Cancer (breast, liposarcoma, prostate) (n=181). Lipoprotein lipase (LPL) and CD36 expression was evaluated on Cell growth and presence of LPL/CD36 in tumor tissues. Cancer cells can use lipoprotein lipase and CD36 to acquire preformed fatty acids from circulating lipoproteins to fuel their growth, as supported by expression in 181 tumor tissues.
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