What is the clinical evidence from this study?

Study design: Other. Population: Breast cancer. Intervention: VLDL and LPL manipulation. Primary outcome: VLDL uptake and lipid acquisition.

December 5, 2019Journal of Lipid ResearchOpen Access

Endocytosis of very low-density lipoproteins: an unexpected mechanism for lipid acquisition by breast cancer cells

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Key result

Breast cancer cells acquire lipids through receptor-mediated endocytosis of intact VLDL particles, a process dependent on lipoprotein lipase bound to heparan sulfate proteoglycans and the VLDL receptor.

Population

Breast cancer cell lines and tissues

Authors

LLLeslie LupienDana-Farber Cancer Institute KBKatarzyna BlochKU Leuven JDJonas DehairsVIB-KU Leuven Center for Cancer Biology

Discussion

Member takes

Implication

May inform breast cancer metabolic targeting; leaves open human relevance from animal data alone.

Structured PICO

Population

In vitro study using human breast cancer cell lines and clinical breast tumor tissue to investigate mechanisms of lipid acquisition.

Intervention

VLDL supplementation, LPL overexpression/knockdown, and inhibitors of endocytosis/binding (heparin, Dynasore, RAP)

Comparator

Control conditions (untreated cells, empty vector, scrambled RNA)

Outcome

VLDL binding and internalization (uptake) and intracellular lipid droplet contentsurrogate

Breast cancer cells can acquire lipids through the uptake of intact VLDL particles via LPL and VLDL receptor-mediated endocytosis, highlighting a metabolic plasticity that may compensate for therapies targeting fatty acid synthesis.

Cite This Study

Lupien et al. (2019) studied Breast cancer. VLDL and LPL manipulation was evaluated on VLDL uptake and lipid acquisition. Breast cancer cells acquire lipids through receptor-mediated endocytosis of intact VLDL particles, a process dependent on lipoprotein lipase bound to heparan sulfate proteoglycans and the VLDL receptor.

synapsesocial.com/papers/6a85b01c3028043586c92b2d https://doi.org/10.1194/jlr.ra119000327

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Endocytosis of very low-density lipoproteins: an unexpected mechanism for lipid acquisition by breast cancer cells

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Endocytosis of very low-density lipoproteins: an unexpected mechanism for lipid acquisition by breast cancer cells

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider