Key result
Cancer cells express LPL and CD36 to acquire fatty acids from circulating lipoproteins, which accelerates their growth and is present in the majority of 181 examined tumor tissues.
Population
Breast cancer, sarcoma, prostate cancer, and HeLa cell lines; human breast, liposarcoma, and prostate tumor…
Comparison
Lipoprotein lipase provision, LPL knockdown, and… vs Control conditions
Design
Preclinical
Authors
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Does not support dietary changes in cancer care yet; hypothesis-generating from animal data and leaves open human translation of LPL/CD36 targeting.
Cancer cells can use LPL and CD36 to acquire preformed fatty acids from the circulation, highlighting a mechanism linking dietary fat to solid tumor proliferation.
Kuemmerle et al. (2011) studied Cancer (breast, liposarcoma, prostate) (n=181). Lipoprotein lipase (LPL) and CD36 expression was evaluated on Presence of LPL and CD36 in tumor tissues and effect on cell growth. Cancer cells express LPL and CD36 to acquire fatty acids from circulating lipoproteins, which accelerates their growth and is present in the majority of 181 examined tumor tissues.
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