Key result
Tumor LPL and CD36 enable cancer cells to acquire circulating fatty acids for growth.
Why the study?
Cancer cells require fatty acids for growth and survival, but the role of lipoprotein lipase and dietary fat uptake in fueling tumor cell proliferation was unclear.
Population
Breast cancer, sarcoma, prostate cancer, and HeLa cell lines and 181 human breast, liposarcoma, and prostate tumor tissues
Comparison
Lipoprotein lipase provision or knockdown and fatty acid synthesis inhibition
Design
Preclinical experimental study
Authors
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May support targeting LPL/CD36 for FA uptake in cancer; leaves open clinical relevance pending human validation.
Cancer cells can utilize lipoprotein lipase and CD36 to acquire fatty acids from the circulation, suggesting a potential therapeutic target involving dietary fat intake and lipolysis.
Coleman et al. (2020) studied Solid tumors (breast, liposarcoma, prostate) (n=181). Lipoprotein lipase (LPL) and CD36 was evaluated on Tumor cell growth and presence of LPL/CD36. Lipoprotein lipase and CD36 were present in the majority of 181 examined breast, liposarcoma, and prostate tumor tissues, allowing cancer cells to acquire circulating fatty acids for growth.
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