Efficacy and Tolerability of a Novel Topical Hydrator Used After Nonablative Laser Skin Rejuvenation

Background Topical hyaluronic acid (HA) has shown promise for improving skin appearance, used alone or in combination with other facial rejuvenation procedures. Aims To assess the efficacy and tolerability of a next‐generation topical hyaluronic acid–containing facial hydrator (HCH) when applied twice daily for 8 weeks after nonablative laser treatment. Methods This 8‐week, single‐center pilot study was conducted among 10 healthy female ( n = 9) and male ( n = 1) participants (aged 28–65 years), with Fitzpatrick skin types II/III/IV, moderate to severe lack of dewiness, and global fine lines/wrinkles, who planned to undergo pre‐elective laser treatment. HCH was applied after laser treatment, then twice daily for 8 weeks. Investigator grading of skin quality and standardized photography were performed before and after laser treatment, immediately after initial HCH application, and at follow‐up visits (day 2; weeks 2/4/8); participant self‐assessments were conducted immediately after initial HCH application and at all follow‐up visits. Results Following the first post‐laser HCH application, investigator assessments indicated significant clinical improvements in skin quality (less dryness/scaling, improved radiance) compared with assessments post‐laser/before HCH application. Continued improvement was noted in investigator‐graded skin quality throughout the 8‐week study. All participants expressed overall satisfaction with HCH. For the vast majority of questionnaire items pertaining to specific benefits of HCH, 90 to 100% of participants agreed/strongly agreed. Conclusions The results of this 8‐week pilot study suggest that the novel skin hydrator HCH pairs well with an in‐office laser procedure, provides immediate and long‐term significant improvements in skin appearance and quality, and enhances the laser treatment experience.