Key result
High negativity and social inhibition link to ~92% higher post-PCI MACE risk versus low inhibition.
Why the study?
Negative emotions adversely affect cardiac prognosis, but whether social inhibition modulates the effect of negative emotions on clinical outcome following PCI was unknown.
Does social inhibition modulate the effect of negative emotions on MACE in patients following PCI?
Population
Eight hundred and seventy-five consecutive patients from the RESEARCH registry 6 months following PCI
Comparison
High negativity and high inhibition vs high negativity and low inhibition
Design
Registry-based cohort study
Follow-up
9 months following assessment
Authors
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May flag higher post-PCI MACE risk when negativity coexists with inhibition; hypothesis-generating and should not yet change practice.
Cohort (n=875)
No
Does social inhibition modulate the effect of negative emotions on MACE in patients following PCI?
Hazard Ratio: 1.92 (95% CI 1.22–3.01)
Absolute Event Rate: 15% vs 10%
p-value: p=0.005
The interaction of social inhibition and negative emotions, rather than negative emotions alone, independently predicts poor clinical outcomes following PCI.
Denollet et al. (2005) conducted a cohort in percutaneous coronary intervention (PCI) (n=875). High negativity and high social inhibition vs. High negativity and low social inhibition was evaluated on major adverse cardiac event (MACE-death, myocardial infarction, coronary artery bypass graft (CABG), or PCI) (HR 1.92, 95% CI 1.22-3.01, p=0.005). High negativity combined with high social inhibition increased the risk of MACE following PCI compared to high negativity with low inhibition (HR 1.92; 95% CI 1.22-3.01; P=0.005).
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