What is the clinical evidence from this study?

Study design: Observational. Population: Takotsubo syndrome (n=376). Intervention: Left ventricular stroke volume index (LVSVi) vs. Higher LVSVi (or ≥35 mL/m²). Primary outcome: Composite of major adverse cardiovascular events and all-cause death (HR 0.96, 95% CI 0.92 to 0.98, p=<0.01).

What does this research mean for the field?

Early cardiac magnetic resonance-derived low left ventricular stroke volume index (LVSVi) is an independent predictor of mid-term major adverse cardiovascular events and mortality in patients with takotsubo syndrome. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

What question did this study set out to answer?

This study aims to evaluate the prognostic significance of CMR-derived left ventricular stroke volume index in patients with takotsubo syndrome.

June 10, 2026Heart0 citations

Prognostic Value of Left Ventricular Stroke Volume Index in Takotsubo Syndrome

Q: What are the key findings of this study?

Left ventricular stroke volume index independently predicted the composite of major adverse cardiovascular events and all-cause death in patients with takotsubo syndrome (HR 0.96; 95% CI 0.92-0.98).

Q: What does this research mean for the field?

Early cardiac magnetic resonance-derived low left ventricular stroke volume index (LVSVi) is an independent predictor of mid-term major adverse cardiovascular events and mortality in patients with takotsubo syndrome. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

Q: What question did this study set out to answer?

This study aims to evaluate the prognostic significance of CMR-derived left ventricular stroke volume index in patients with takotsubo syndrome.

Independent prognostic value of left ventricular stroke volume index in patients with takotsubo syndrome: insights from the EVOLUTION registry

View Full Paper

Ask AI

Bookmark

Why the study?

The prognostic relevance of cardiac magnetic resonance in takotsubo syndrome is not fully elucidated.

Does CMR-derived left ventricular stroke volume index predict major adverse cardiovascular events and all-cause death in patients with takotsubo syndrome?

Population

376 consecutive patients with TTS

Comparison

CMR-derived LVSVi <35 vs ≥35 mL/m²

Design

Observational study

Follow-up

Median 360 days

Key result

Left ventricular stroke volume index independently predicted the composite of major adverse cardiovascular events and all-cause death in patients with takotsubo syndrome (HR 0.96; 95% CI 0.92-0.98).

Authors

LALuca Arcari RCRiccardo Cau GPGianluca Pontone

Discussion

Member takes

Overview

May support LVSVi for mid-term prognostication in takotsubo syndrome; hypothesis-generating and requires prospective validation.

Key Points

This study aims to evaluate the prognostic significance of CMR-derived left ventricular stroke volume index in patients with takotsubo syndrome.
Consecutive patients with takotsubo syndrome underwent cardiac magnetic resonance imaging after admission.
Patients were categorized based on left ventricular stroke volume indexed (<35 vs ≥35 mL/m²).
Follow-up lasted a median of 360 days, with focus on major adverse cardiovascular events and all-cause death.
In the low LVSVi group (<35 mL/m²), event rates for primary and secondary endpoints were significantly higher (log-rank p<0.01).
LVSVi was identified as an independent predictor of both primary (HR 0.96; 95% CI 0.92 to 0.98) and secondary endpoints (HR 0.95; 95% CI 0.90 to 0.99).
Patients with high LVSVi and normal LVEF had the lowest event rates (log-rank p<0.01).

Study Design

Type

Observational (n=376)

Structured PICO

Does CMR-derived left ventricular stroke volume index predict major adverse cardiovascular events and all-cause death in patients with takotsubo syndrome?

Population

376 patients with takotsubo syndrome (mean age 70 years, 91% female) who underwent early cardiac magnetic resonance imaging, followed for a median of 360 days.

Exposure

CMR-derived left ventricular stroke volume indexed (LVSVi) <35 mL/m²

Comparator

CMR-derived LVSVi ≥35 mL/m²

Outcome

Composite of major adverse cardiovascular events and all-cause-deathcomposite

Early CMR-derived left ventricular stroke volume index is an independent predictor of mid-term outcomes in patients with takotsubo syndrome, identifying a low-risk subgroup when combined with recovered LVEF.

Main Result

Hazard Ratio: 0.96 (95% CI 0.92–0.98)

p-value: p=<0.01

Cite This Study

Arcari et al. (2026) conducted an observational in Takotsubo syndrome (n=376). Left ventricular stroke volume index (LVSVi) vs. Higher LVSVi (or ≥35 mL/m²) was evaluated on Composite of major adverse cardiovascular events and all-cause death (HR 0.96, 95% CI 0.92 to 0.98, p=<0.01). Left ventricular stroke volume index independently predicted the composite of major adverse cardiovascular events and all-cause death in patients with takotsubo syndrome (HR 0.96; 95% CI 0.92-0.98).

synapsesocial.com/papers/6a28fe9f6f82f25be989be85 https://doi.org/10.1136/heartjnl-2026-327797

View Full Paper

Ask AI

Bookmark

June 10, 2026Heart0 citations

Prognostic Value of Left Ventricular Stroke Volume Index in Takotsubo Syndrome

Independent prognostic value of left ventricular stroke volume index in patients with takotsubo syndrome: insights from the EVOLUTION registry

View Full Paper

Ask AI

Bookmark

Why the study?

The prognostic relevance of cardiac magnetic resonance in takotsubo syndrome is not fully elucidated.

Does CMR-derived left ventricular stroke volume index predict major adverse cardiovascular events and all-cause death in patients with takotsubo syndrome?

Population

376 consecutive patients with TTS

Comparison

CMR-derived LVSVi <35 vs ≥35 mL/m²

Design

Observational study

Follow-up

Median 360 days

Key result

Left ventricular stroke volume index independently predicted the composite of major adverse cardiovascular events and all-cause death in patients with takotsubo syndrome (HR 0.96; 95% CI 0.92-0.98).

Authors

LALuca Arcari RCRiccardo Cau GPGianluca Pontone

Discussion

Member takes

Overview

May support LVSVi for mid-term prognostication in takotsubo syndrome; hypothesis-generating and requires prospective validation.

Key Points

This study aims to evaluate the prognostic significance of CMR-derived left ventricular stroke volume index in patients with takotsubo syndrome.
Consecutive patients with takotsubo syndrome underwent cardiac magnetic resonance imaging after admission.
Patients were categorized based on left ventricular stroke volume indexed (<35 vs ≥35 mL/m²).
Follow-up lasted a median of 360 days, with focus on major adverse cardiovascular events and all-cause death.
In the low LVSVi group (<35 mL/m²), event rates for primary and secondary endpoints were significantly higher (log-rank p<0.01).
LVSVi was identified as an independent predictor of both primary (HR 0.96; 95% CI 0.92 to 0.98) and secondary endpoints (HR 0.95; 95% CI 0.90 to 0.99).
Patients with high LVSVi and normal LVEF had the lowest event rates (log-rank p<0.01).

Study Design

Type

Observational (n=376)

Structured PICO

Does CMR-derived left ventricular stroke volume index predict major adverse cardiovascular events and all-cause death in patients with takotsubo syndrome?

Population

376 patients with takotsubo syndrome (mean age 70 years, 91% female) who underwent early cardiac magnetic resonance imaging, followed for a median of 360 days.

Exposure

CMR-derived left ventricular stroke volume indexed (LVSVi) <35 mL/m²

Comparator

CMR-derived LVSVi ≥35 mL/m²

Outcome

Composite of major adverse cardiovascular events and all-cause-deathcomposite

Main Result

Hazard Ratio: 0.96 (95% CI 0.92–0.98)

p-value: p=<0.01

Cite This Study

synapsesocial.com/papers/6a28fe9f6f82f25be989be85 https://doi.org/10.1136/heartjnl-2026-327797

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

View Full Paper

Ask AI

Bookmark