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This study aims to propose a method for quantifying the kinetics of proglucagon-derived peptide fragments.

June 10, 2026Diabetes

1330-OR: Quantifying the Kinetics of Proglucagon-Derived Peptide Fragments Using Somatostatin and Glucagon Infusion

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This study aims to propose a method for quantifying the kinetics of proglucagon-derived peptide fragments.
Measured plasma levels of glucagon, glicentin, major proglucagon fragment, and oxyntomodulin during somatostatin infusion over 1 hour.
Used a single compartment model to describe the decay of the proglucagon fragments based on their half-lives.
Calculated the volume of distribution for major proglucagon fragment using the knowledge of its secretion alongside glucagon.
The model fitted well with kinetic parameters: t1/2(MPGF) = 44 ± 3 min, t1/2(GLY) = 29 ± 4 min, t1/2(OXM) = 76 ± 17 min.
Volume of distribution for MPGF was calculated as 15 ± 3 L.
The method enables future calculations of secretion rates, aiding in early detection of α-cell dysfunction.

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Randomized trial quantifies proglucagon fragment kinetics during somatostatin infusion, suggesting insights into α-cell function.

BOSCOLO et al. (2026) studied this question.

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