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This report aims to describe an unusual case of seizure following the administration of ketamine and propofol for procedural sedation.

June 10, 2026Open Access

Seizure in a Patient Who Received Propofol and Ketamine for Procedural Sedation; a Case Report

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This report aims to describe an unusual case of seizure following the administration of ketamine and propofol for procedural sedation.
Case report of a 60-year-old man receiving ketamine and propofol for shoulder dislocation correction in the emergency department.
Patient experienced a generalized tonic-clonic seizure 2 minutes after administration without prior seizure history.
The events were monitored with supportive care for resolution, and the patient was discharged after observation.
The patient experienced a generalized tonic-clonic seizure characterized by upward gaze and urinary incontinence two minutes post-sedation.
Resolution of seizure occurred within one minute without the use of anticonvulsant medication.
The patient was fully awake and discharged after 6 hours of observation.

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Case report highlights seizure occurrence after sedation with ketamine and propofol in emergency settings, indicating need for vigilance.

Nikpour et al. (2023) studied this question.

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