Key result
A single high-fat meal increased endothelial microparticle levels after 3 hours from 389 to 677 thousands per milliliter, correlating with postprandial triglycerides.
Why the study?
Does a single high-fat meal increase circulating levels of endothelial cell microparticles in healthy subjects?
Does a single high-fat meal increase circulating levels of endothelial cell microparticles in healthy subjects?
A single high-fat meal acutely increases circulating endothelial microparticles, suggesting that postprandial hypertriglyceridemia may induce transient endothelial dysfunction or injury.
Answers are grounded in this paper and cite their sources.
May transiently signal endothelial stress after high-fat meals in healthy adults; leaves open clinical relevance and need for outcome trials.
BACKGROUND: This study evaluated a possible relationship between levels of endothelial microparticles (EMPs), known to be a sensitive indicator of endothelial disturbance, and changes in postprandial lipid levels in healthy volunteers after a low- or high-fat meal. METHODS AND RESULTS: Eighteen healthy subjects without known cardiovascular risk factors were evaluated. Lipid and EMP levels were measured before and 1 and 3 hours after a single low- or high-fat isocaloric meal. The low-fat meal had no significant postprandial effect on EMPs or lipids compared with fasting levels. In contrast, a single high-fat meal significantly increased EMP levels after 1 and 3 hours, from 389+/-54 (thousands per milliliter) when fasting to 541+/-139 (P=0.0002) and 677+/-159 (P<0.0001), respectively, and correlated with a postprandial elevation in serum triglycerides. CONCLUSIONS: A single high-fat meal led to a significant elevation of plasma EMP levels in healthy, normolipidemic subjects and correlated with a postprandial elevation of serum triglycerides. EMPs may be an indirect marker of endothelial dysfunction or injury induced by postprandial triglyceride-rich lipoproteins.
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Ferreira et al. (2004) studied Healthy (n=18). High-fat meal vs. Low-fat meal and fasting levels was evaluated on Endothelial microparticle (EMP) levels at 3 hours (thousands per milliliter) (p=<0.0001). A single high-fat meal increased endothelial microparticle levels after 3 hours from 389 to 677 thousands per milliliter, correlating with postprandial triglycerides.
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