Palladium Catalyzed Direct meta-C-H Functionalization of Aryl Acetic Esters

Manickam Bakthadoss; Shaw Rajlaxmi; Alapati Yaswanth; Sivasubramaniyan Kavikumar

doi:10.1039/d6cc02178f

January 1, 2026Chemical Communications

Palladium Catalyzed Direct meta-C-H Functionalization of Aryl Acetic Esters

View Full Paper

Ask AI

Bookmark

Share

Key Points

To explore the palladium(II)-catalyzed direct meta-C–H functionalization of aryl acetic esters for regioselective synthesis.
Utilized palladium(II) as a catalyst for functionalization of aryl acetic esters.
Conducted olefination reactions with maleimides and naphthoquinone as coupling partners.
Achieved good yields in regioselective reactions.
Successful meta-C–H functionalization was achieved with weakly coordinating aryl acetic esters.
Olefination reactions with maleimides and naphthoquinone showed good yield with defined regioselectivity.

Implication

Research reveals a palladium-catalyzed technique enabling regioselective olefination in aryl acetic esters, highlighting new synthetic possibilities.

Abstract

Herein, we report a palladium (II)-catalyzed direct meta-C–H functionalization of weakly coordinating aryl acetic esters, enabling regioselective olefination with maleimides and naphthoquinone as the coupling partners with good yields and...

Discussion

No takes yet. Share an insight, caveat, or question.

Cite This Study

Bakthadoss et al. (2026) studied this question.

synapsesocial.com/papers/6a2a51d780c8f91e7f39df88 https://doi.org/10.1039/d6cc02178f

View Full Paper

Ask AI

Bookmark

Share

Palladium Catalyzed Direct meta-C-H Functionalization of Aryl Acetic Esters

Key Points

Implication

Abstract

Discussion

Cite This Study

Palladium Catalyzed Direct meta-C-H Functionalization of Aryl Acetic Esters

Key Points

Implication

Abstract

Discussion

Cite This Study

Keep reading

Keep reading