December 1, 2015Circulation Cardiovascular Imaging
Sixty-Four–Section Cardiac Computed Tomography in Mechanical Prosthetic Heart Valve Dysfunction
Key result
64-slice MDCT accurately distinguished pannus from thrombus in prosthetic valve dysfunction, with an AUC of 0.96 (95% CI 0.91-0.99; P<0.001).
Why the study?
Does 64-slice MDCT accurately distinguish between pannus and thrombus in patients with suspected mechanical prosthetic valve dysfunction?
Population
62 patients with suspected mechanical prosthetic valve dysfunction assessed by transesophageal…
Comparison
64-slice multidetector computed tomography to… vs Definitive diagnosis by thrombolysis response or…
Design
Cohort
Authors
Discussion
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Implication
May support MDCT differentiation of prosthetic masses; hypothesis-generating and requires validation before guiding therapy.
Study Design
Type
Observational (n=62)
Structured PICO
Does 64-slice MDCT accurately distinguish between pannus and thrombus in patients with suspected mechanical prosthetic valve dysfunction?
P
Population
62 patients (mean age 44 years, 63% female) with suspected mechanical prosthetic valve dysfunction assessed by transesophageal echocardiography.
E
Exposure
64-slice multidetector computed tomography (MDCT) to measure attenuation values (Hounsfield Units) of periprosthetic masses.
C
Comparator
Definitive diagnosis by thrombolysis response or surgical findings (thrombus vs. pannus).
O
Outcome
Discrimination between pannus and thrombus based on MDCT attenuation values (Hounsfield Units).surrogate
Main Result
Effect estimate: AUC 0.96 (95% CI 0.91-0.99)
Absolute Event Rate: 87% vs 322%
p-value: p=<0.001
64-slice MDCT attenuation values can accurately distinguish between pannus and thrombus in mechanical prosthetic valve dysfunction, guiding the selection of thrombolysis versus surgery.
Cite This Study
Gündüz et al. (2015) conducted an observational in Mechanical prosthetic heart valve dysfunction (n=62). 64-slice multidetector computed tomography (MDCT) was evaluated on Mean attenuation value (Hounsfield Units) and discrimination of pannus from thrombus (AUC 0.96, 95% CI 0.91-0.99, p=<0.001). 64-slice MDCT accurately distinguished pannus from thrombus in prosthetic valve dysfunction, with an AUC of 0.96 (95% CI 0.91-0.99; P<0.001).