Key result
Optimal management of AHF in CAD remains poorly defined and urgently requires prospective trials.
Why the study?
Although the majority of patients admitted with AHFS have CAD, management of AHFS in patients with CAD is less well defined compared to ACS complicated by heart failure.
Highlights the need for prospective studies to better define the assessment and treatment of coronary artery disease in patients presenting with acute heart failure syndromes.
Answers are grounded in this paper and cite their sources.
High early mortality in AHFS-CAD may warrant intensified post-discharge surveillance; hypothesis-generating for refined management strategies.
Acute heart failure syndromes (AHFS) have emerged as a leading public health problem worldwide, accounting for a substantial number of hospitalizations and a high utilization of resources. Although in-hospital mortality rates are relatively low, patients with AHFS have very high early after-discharge mortality and rehospitalization rates. The majority of patients admitted with AHFS have coronary artery disease (CAD), which independently has an adverse impact on prognosis. The initial in-hospital and after-discharge management of AHFS may be dependent on clinical presentation: AHFS in patients with underlying CAD or acute coronary syndromes (ACS) complicated by heart failure. In addition, the extent and severity of CAD and the presence of ischemia and/or stunned/hibernating myocardium should be assessed for optimal management. Although the overall management of AHFS with CAD may be similar to that in patients with ACS complicated by heart failure, for which specific guidelines exist, management of the former is less well defined. Prospective studies of the assessment and treatment of CAD in patients with AHFS are urgently needed.
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Flaherty et al. (2009) conducted a review in Acute Heart Failure Syndromes (AHFS) with Coronary Artery Disease (CAD). The management of acute heart failure syndromes in patients with underlying coronary artery disease is poorly defined, highlighting an urgent need for prospective studies.
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