Chemoselective Reduction of Thioureas to N-Methylamines and N,N-Dimethylamines Using Cu-based Catalyst

Yuanchen Jie; Jun Zhu; Yongtao Wang; Jia Yao; Haoran Li

doi:10.1039/d6su00242k

January 1, 2026RSC SustainabilityOpen Access

Chemoselective Reduction of Thioureas to N-Methylamines and N,N-Dimethylamines Using Cu-based Catalyst

View Full Paper

Ask AI

Bookmark

Share

Key Points

This research aims to develop a copper-catalyzed method for reducing thioureas to N-methylamines and N,N-dimethylamines.
Utilized a copper-based catalyst for the hydrogenative reduction of thioureas.
Employed PhSiH3 as the hydrogenation reagent in 10 distinct examples.
Achieved carbon utilization rates ranging from 42% to 99%.
Successfully converted thioureas to N-methylamines and N,N-dimethylamines across all examples.
Demonstrated high efficiency with a carbon utilization rate of 99% in optimal conditions.
Reported a range of effectiveness with varying rates between 42% to 99% across tested samples.

Ask about this paper

Answers are grounded in this paper and cite their sources.

Implication

Demonstrates efficient reduction of thioureas to N-methylamines in a copper-catalyzed reaction, implying improved synthetic methods.

Abstract

We report a general copper-catalyzed hydrogenative reduction of thioureas to N-methylamine and N,N-dimethylamine (10 examples, 42-99% carbon utilization rate) using PhSiH3 as the hydrogenation reagent, which realize the highly efficient...

Discussion

No takes yet. Share an insight, caveat, or question.

Cite This Study

Jie et al. (2026) studied this question.

synapsesocial.com/papers/6a2e4779b1cc60ccdea8bfa1 https://doi.org/10.1039/d6su00242k

View Full Paper

Ask AI

Bookmark

Share

Chemoselective Reduction of Thioureas to N-Methylamines and N,N-Dimethylamines Using Cu-based Catalyst

Key Points

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

Chemoselective Reduction of Thioureas to N-Methylamines and N,N-Dimethylamines Using Cu-based Catalyst

Key Points

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

Keep reading

Keep reading