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June 14, 2026RSC SustainabilityOpen Access

Chemoselective Reduction of Thioureas to N-Methylamines and N,N-Dimethylamines Using Cu-based Catalyst

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Authors

YJYuanchen JieJZJun ZhuYWYongtao Wang

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Overview

Randomized trial demonstrates efficient reduction of thioureas to N-methylamines in a copper-catalyzed reaction, implying improved synthetic methods.

Key Points

  • This research aims to develop a copper-catalyzed method for reducing thioureas to N-methylamines and N,N-dimethylamines.
  • Utilized a copper-based catalyst for the hydrogenative reduction of thioureas.
  • Employed PhSiH3 as the hydrogenation reagent in 10 distinct examples.
  • Achieved carbon utilization rates ranging from 42% to 99%.
  • Successfully converted thioureas to N-methylamines and N,N-dimethylamines across all examples.
  • Demonstrated high efficiency with a carbon utilization rate of 99% in optimal conditions.
  • Reported a range of effectiveness with varying rates between 42% to 99% across tested samples.

Cite This Study

Jie et al. (2026) studied this question.

synapsesocial.com/papers/6a2e4779b1cc60ccdea8bfa1https://doi.org/10.1039/d6su00242k
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