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June 15, 2026International Journal of GenomicsOpen Access

Investigation of Pharmacogenomic Variants in the CYP (P450) Family in Native American Populations of the Brazilian Amazon

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Authors

LFLilian Marques de FreitasJRJuliana Carla Gomes RodriguesFMFrancisco Cézar Aquino de Moraes

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Overview

Randomized trial investigates genetic variation in CYP genes in Indigenous populations, suggesting implications for personalized medicine.

Key Points

  • This study aims to characterize genetic variation within CYP genes in Native American populations from the Brazilian Amazon.
  • Whole-exome sequencing data were generated for 64 Indigenous individuals from 12 distinct Amazonian ethnic groups.
  • 506 genetic variants were detected across 63 CYP genes, with functional effects assessed and annotated.
  • Comparative analyses were performed to relate observed variant patterns with those of global populations.
  • A total of 506 genetic variants were identified, with 300 predicted to have modifying effects.
  • Eleven variants were novel and not previously annotated in available databases.
  • Distinct variant distributions compared to global reference populations were observed.

Cite This Study

Freitas et al. (2026) studied this question.

synapsesocial.com/papers/6a2f97c8a1cfeec490828d8chttps://doi.org/10.1155/ijog/5804093
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