November 25, 2014Current Opinion in Nephrology & Hypertension
Arterial stiffness
Key result
Carotid-femoral pulse-wave velocity has emerged as the reference standard measure of aortic stiffness and a powerful predictor of cardiovascular disease risk and target organ damage.
Why the study?
Does arterial stiffness contribute to the pathogenesis of hypertension and target organ damage?
Population
Data from comprehensive hemodynamic profiles obtained in the Framingham Heart Study and the Age…
Design
Review
Authors
Discussion
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Member takes
Implication
CFPWV may refine hypertension risk assessment in practice; extends observational data linking aortic stiffness to target organ damage.
Structured PICO
Does arterial stiffness contribute to the pathogenesis of hypertension and target organ damage?
P
Population
Data from comprehensive hemodynamic profiles obtained in the Framingham Heart Study and the Age, Gene/Environment Susceptibility-Reykjavik Study
E
Exposure
Measures of arterial stiffness (e.g., Carotid-femoral pulse-wave velocity [CFPWV], augmentation index)
O
Outcome
Blood pressure and target organ damage (heart, brain, kidneys)
Aortic stiffness, measured by CFPWV, is not merely a consequence of hypertension but actively contributes to its pathogenesis and subsequent microvascular target organ damage.
Cite This Study
Gary F. Mitchell (2014) conducted a review in Arterial stiffness and hypertension. Arterial stiffness was evaluated. Carotid-femoral pulse-wave velocity has emerged as the reference standard measure of aortic stiffness and a powerful predictor of cardiovascular disease risk and target organ damage.