Key result
Non-HDL-cholesterol levels of 140-159 mg/dL were associated with a significantly increased risk of coronary heart disease (HR 2.49) compared to levels <100 mg/dL in a Japanese general population.
Why the study?
Do higher non-HDL-cholesterol levels increase the incidence of coronary heart disease in a healthy Japanese general population?
Population
8,132 men and women, aged 40 to 69 years with no history of stroke or coronary heart disease at baseline…
Comparison
Higher non-HDL-cholesterol levels vs Lower non-HDL-cholesterol levels
Design
Cohort, The final diagnosis of CHD was made by a panel of three or four…
Follow-up
median 21.9 years
Authors
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Non-HDL-C ≥140 mg/dL may flag higher CHD risk in Japanese adults; leaves open whether lowering it reduces events.
Cohort (n=8,132)
Yes
Do higher non-HDL-cholesterol levels increase the incidence of coronary heart disease in a healthy Japanese general population?
Hazard Ratio: 2.49 (95% CI 1.35–4.61)
In a Japanese general population, non-HDL-cholesterol levels ≥140 mg/dL are associated with a significantly increased risk of incident coronary heart disease over a 22-year follow-up.
Kitamura et al. (2011) conducted a cohort in Coronary Heart Disease (n=8,132). Non-HDL-cholesterol levels (140-159 mg/dL) vs. Non-HDL-cholesterol <100 mg/dL was evaluated on Incidence of Coronary Heart Disease (CHD) (HR 2.49, 95% CI 1.35-4.61). Non-HDL-cholesterol levels of 140-159 mg/dL were associated with a significantly increased risk of coronary heart disease (HR 2.49) compared to levels <100 mg/dL in a Japanese general population.
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