Key result
A 5 mg/dL decrease in high-density lipoprotein cholesterol was associated with a 21% increased risk of coronary artery disease (HR 1.21) in Japanese men.
Why the study?
Do lower levels of HDL-C increase the risk of incident coronary artery disease in Japanese men?
Cohort (n=5,371)
No
Do lower levels of HDL-C increase the risk of incident coronary artery disease in Japanese men?
Hazard Ratio: 1.21 (95% CI 1.11–1.33)
p-value: p=<0.001
Low HDL-C (<51 mg/dL) is a significant and independent risk factor for the development of coronary artery disease in Japanese men over a 12-year period.
Low HDL-C may aid CAD risk stratification in Japanese men; extends prior data but leaves causality and intervention effects open.
AIM: Lower levels of high-density lipoprotein cholesterol (HDL-C) have been recognized as a risk factor for coronary artery disease (CAD), but the relationship between HDL-C values and the occurrence of CAD has not been fully established in the Japanese general population. METHODS: A cohort study of 5,371 Japanese men with 12 years of follow-up was conducted to identify risk factors for the occurrence of CAD. RESULTS: One hundred and twelve subjects had CAD (acute myocardial infarction in 67 patients and angina in 45 patients) during the follow-up period. Adjustment for variables including age, body mass index, smoking habit, alcohol intake, systolic blood pressure, low-density lipoprotein cholesterol, triglyceride, fasting plasma glucose, hypertension, diabetes mellitus and hyperlipidemia, adjusted hazard ratio (HR) of lower levels of HDL-C for the occurrence of CAD was 1.21 (95% confidence interval (CI): 1.11-1.33, p<0.001). Serum HDL-C concentration less than 51 mg/dL was a significant risk for CAD. CONCLUSIONS: Low HDL-C was identified as a significant and independent risk for CAD in Japanese men using long-term follow-up data.
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Satoh et al. (2009) conducted a cohort in Coronary Artery Disease (n=5,371). 5 mg/dL decrease in HDL-C vs. Higher HDL-C levels was evaluated on Occurrence of coronary artery disease (acute myocardial infarction and/or angina pectoris) (HR 1.21, 95% CI 1.11-1.33, p=<0.001). A 5 mg/dL decrease in high-density lipoprotein cholesterol was associated with a 21% increased risk of coronary artery disease (HR 1.21) in Japanese men.
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