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April 3, 2025INDONESIAN JOURNAL OF MEDICAL LABORATORY SCIENCE AND TECHNOLOGYOpen Access

Betatrophin: A promising biomarker for metabolic syndrome and diabetes mellitus risk screening in teenagers

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Key result

Circulating betatrophin levels correlate with BMI, SBP, and FBG in healthy teenagers.

  • P<0.05
  • n=90

Why the study?

Metabolic syndrome and diabetes mellitus are rising concerns in youth, and boarding schools may foster metabolic disease due to daily dietary intake.

Do circulating betatrophin and GAD65 levels correlate with metabolic syndrome and diabetes risk factors in healthy teenagers?

Population

90 healthy senior and junior high school students

Design

Observational study

Authors

HSHendra SusantoAAAulanni’am Aulanni’amDWDyah Kinasih Wuragil

Discussion

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Member takes

Overview

Betatrophin may mark metabolic risk in teens; hypothesis-generating and should not yet change practice.

Study Design

Type

Observational (n=90)

Structured PICO

Do circulating betatrophin and GAD65 levels correlate with metabolic syndrome and diabetes risk factors in healthy teenagers?

P
Population
90 healthy senior and junior high school students at an Indonesian Boarding School assessed for metabolic syndrome and diabetes risk.
E
Exposure
Measurement of circulating betatrophin levels (via ELISA) and 65 kDa glutamic acid decarboxylase (GAD65) (via rapid reverse-flow immunochromatography)
O
Outcome
Correlation of circulating betatrophin levels with metabolic syndrome and diabetes risk factors (age, gender, BMI, SBP, FBG, sleeping duration, duration of stay)surrogate

Main Result

p-value: p=<0.05

Betatrophin and GAD65 show promise as potential biomarkers for screening metabolic syndrome and diabetes mellitus risk in teenagers.

Cite This Study

Susanto et al. (2025) conducted an observational in Metabolic syndrome and diabetes mellitus risk (n=90). Circulating betatrophin levels was evaluated on Correlation with BMI, systolic blood pressure, and fasting blood glucose (p=<0.05). Circulating betatrophin levels significantly correlated with BMI, systolic blood pressure, and fasting blood glucose in healthy boarding school teenagers (p < 0.05).

synapsesocial.com/papers/6a31679bdd75cb1e836e86dfhttps://doi.org/10.33086/ijmlst.v7i1.6028
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Circulating betatrophin/ANGPTL8 levels correlate with body fat distribution in individuals with normal glucose tolerance but not those with glucose disorders2020 · 12 citations
  2. 2Increased serum levels of betatrophin in pancreatic cancer-associated diabetes2016 · 12 citations
  3. 3Betatrophin and Insulin Resistance2022 · 15 citations
  4. 4The association of the betatrophin level with metabolic and inflammatory parameters in infertile women with polycystic ovary syndrome: A case-control study2022 · 6 citations
  5. 5Factors associated with diabetes mellitus among adults: Findings from the Indonesian Family Life Survey-52024 · 18 citations