November 8, 2010Catheterization and Cardiovascular Interventions
Frequency, determinants, and prognostic effects of acute kidney injury and red blood cell transfusion in patients undergoing transcatheter aortic valve implantation
Why the study?
What are the predictors of acute kidney injury and its impact on mortality in patients undergoing transcatheter aortic valve implantation?
Population
118 patients undergoing transcatheter aortic valve implantation with the Medtronic CoreValve Revalving System
Design
Cohort
Follow-up
median 13 months
Authors
Discussion
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Member takes
Implication
RBC transfusion may heighten post-TAVI AKI and mortality risk; hypothesis-generating for transfusion minimization trials.
Structured PICO
What are the predictors of acute kidney injury and its impact on mortality in patients undergoing transcatheter aortic valve implantation?
P
Population
118 patients undergoing transcatheter aortic valve implantation (TAVI) with the Medtronic CoreValve Revalving System (excluding patients on chronic hemodialysis and intraprocedural deaths)
I
Intervention
Transcatheter aortic valve implantation (TAVI)
O
Outcome
Frequency and independent predictors of acute kidney injury (AKI), and prognostic implications of AKI and periprocedural red blood cell (RBC) transfusions on 30-day and cumulative late mortalityhard clinical
In patients undergoing TAVI, periprocedural RBC transfusion predicts acute kidney injury, which in turn is a strong independent predictor of both 30-day and late mortality.
Cite This Study
Nuis et al. (2010) studied this question.