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July 20, 2018Nephrology Dialysis Transplantation

Acute kidney injury after transcatheter aortic valve implantation and mortality risk—long-term follow-up

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Why the study?

Does periprocedural acute kidney injury increase the risk of long-term mortality in patients undergoing TAVI for severe aortic stenosis?

Population

1,086 consecutive patients undergoing transcatheter aortic valve implantation for severe aortic stenosis.

Comparison

Periprocedural acute kidney injury defined by… vs No periprocedural acute kidney injury.

Design

Cohort

Follow-up

up to 7 years

Authors

OBOrit Kliuk‐Ben BassatFoundation for Innovative New DiagnosticsAFAriel FinkelsteinInterventional CardiologySBSamuel BazanTel Aviv Sourasky Medical Center

Discussion

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Implication

Periprocedural AKI after TAVI was associated with higher long-term mortality; extends short-term data but leaves open whether prevention improves survival.

Structured PICO

Does periprocedural acute kidney injury increase the risk of long-term mortality in patients undergoing TAVI for severe aortic stenosis?

P
Population
1,086 consecutive patients undergoing transcatheter aortic valve implantation (TAVI) for severe aortic stenosis.
I
Intervention
Periprocedural acute kidney injury (AKI) defined by VARC-2 criteria (absolute increase in serum creatinine ≥0.3 mg/dL or >50% within the first week following TAVI).
C
Comparator
No periprocedural acute kidney injury.
O
Outcome
Long-term mortality (up to 7 years).hard clinical

Periprocedural acute kidney injury following TAVI is associated with significantly increased short-term and long-term (up to 7 years) mortality, highlighting the need for preventive strategies.

Cite This Study

Bassat et al. (2018) studied this question.

synapsesocial.com/papers/6a719723f44fa9f079df5c73https://doi.org/10.1093/ndt/gfy264

Topics

TAVR in low-risk patientsTranscatheter aortic valve replacement
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1The Risk of Acute Kidney Injury and Its Impact on 30-Day and Long-Term Mortality after Transcatheter Aortic Valve Implantation2012 · 32 citations
  2. 2Frequency, determinants, and prognostic effects of acute kidney injury and red blood cell transfusion in patients undergoing transcatheter aortic valve implantation2010 · 148 citations
  3. 3The effects of VARC-defined acute kidney injury after transcatheter aortic valve implantation (TAVI) using the Edwards bioprosthesis2012 · 80 citations
  4. 4Transcatheter Versus Surgical Aortic Valve Replacement in Low-Risk Patients for the Treatment of Severe Aortic Stenosis2020 · 16 citations
  5. 5Transcatheter or Surgical Aortic-Valve Replacement in Intermediate-Risk Patients2016 · 5,111 citations