Risk factors for worsening renal function and their association with long-term mortality following transcatheter aortic valve implantation: data from the SWEDEHEART registry
Key result
Persistent acute kidney injury occurred in 6.1% of patients following TAVI and was associated with a doubled risk of long-term mortality (HR 2.04; 95% CI 1.49-2.81; p<0.001).
Why the study?
Does persistent acute kidney injury increase long-term mortality in patients undergoing TAVI?
Population
1540 patients undergoing and surviving TAVI included in the nationwide SWEDEHEART registry between 2008 and…
Comparison
Persistent acute kidney injury following TAVI vs No persistent acute kidney injury
Design
Cohort
Follow-up
Median 1.8 years (IQR 0.7-3.0)
Authors
Discussion
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Member takes
Implication
May warrant closer post-TAVI renal surveillance; leaves open whether preventing persistent AKI improves survival.
Study Design
Type
Cohort (n=1,540)
Multicenter
Yes
Structured PICO
Does persistent acute kidney injury increase long-term mortality in patients undergoing TAVI?
P
Population
1,540 patients undergoing and surviving TAVI, excluding those with severe baseline renal impairment or on dialysis, followed for a median of 1.8 years.
E
Exposure
Persistent acute kidney injury (pAKI) following TAVI
C
Comparator
No persistent acute kidney injury
O
Outcome
Long-term mortalityhard clinical
Main Result
Hazard Ratio: 2.04 (95% CI 1.49–2.81)
p-value: p=<0.001
Persistent acute kidney injury occurs in approximately 6% of TAVI patients and is independently associated with a doubled risk of long-term mortality.
Cite This Study
Vavilis et al. (2017) conducted a cohort in Patients undergoing transcatheter aortic valve implantation (TAVI) (n=1,540). Persistent acute kidney injury (pAKI) vs. No persistent acute kidney injury was evaluated on Long-term mortality (HR 2.04, 95% CI 1.49 to 2.81, p=<0.001). Persistent acute kidney injury occurred in 6.1% of patients following TAVI and was associated with a doubled risk of long-term mortality (HR 2.04; 95% CI 1.49-2.81; p<0.001).