Key result
Angiotensin II type 2 receptor activation induces apoptosis by activating MAP kinase phosphatase-1, which inhibits MAP kinase and dephosphorylates Bcl-2.
Population
PC12W (rat pheochromocytoma cell line) cells expressing abundant AT2 receptor but not Ang II type 1 receptor
Comparison
Angiotensin II and/or nerve growth factor, with… vs Control conditions
Design
Preclinical
Authors
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AT2-MKP-1 apoptosis pathway may inform future cardiovascular targets; leaves open translation from cell models to clinical use.
The AT2 receptor induces apoptosis by activating MAP kinase phosphatase-1, which inhibits MAP kinase activation and leads to the dephosphorylation and inactivation of the survival factor Bcl-2.
Horiuchi et al. (1997) studied this question. Angiotensin II vs. Nerve growth factor (NGF) alone / Control was evaluated on Bcl-2 phosphorylation and apoptosis. Angiotensin II type 2 receptor activation induces apoptosis by activating MAP kinase phosphatase-1, which inhibits MAP kinase and dephosphorylates Bcl-2.
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