Elevated brachial systolic pressure in 6 young men was caused by pressure wave amplification rather than true hypertension, representing an extreme of the normal pressure wave pattern in youth.
Case Report (n=6)
Young men diagnosed with systolic hypertension may have spurious hypertension due to extreme pressure wave amplification in the upper limbs despite normal central pressures.
Six young men diagnosed with systolic hypertension had normal carotid pressure wave contours, normal synthesized aortic pressure wave contours and normal diastolic and mean pressures in upper limb arteries. Elevated brachial systolic pressure was caused by a high narrow systolic peak of the pressure wave. This was attributed to amplification of the pressure wave between the ascending aorta and upper limb (radial and brachial) arteries that is associated with attainment of full body length and very distensible arteries. These young men were not truly hypertensive. Exaggeration of the upper limb systolic peak represented an extreme of the normal pressure wave pattern in youth, where amplification is greater than in childhood or in older subjects. This phenomenon accounts for the rapid increase in systolic pressure between the ages of 5 and 20 years, and the relative plateau in systolic pressure between the ages of 20 and 45 years that is seen in population studies.
O’Rourke et al. (Tue,) conducted a case report in Systolic hypertension (n=6). Pressure wave amplification was evaluated on Hemodynamic characteristics (pressure wave contours and central pressures). Elevated brachial systolic pressure in 6 young men was caused by pressure wave amplification rather than true hypertension, representing an extreme of the normal pressure wave pattern in youth.
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