Key result
Flow-mediated dilatation was significantly higher in young subjects (7.8%) than in sedentary older subjects (5.2%, P<0.05), and time to peak diameter was significantly longer in older groups.
Why the study?
Does continuous measurement of flow-mediated dilatation (FMD) improve the accuracy of endothelial function assessment compared to traditional fixed-time measurement in young and older subjects?
Population
36 subjects including 12 young, 12 fitness matched older, and 12 older untrained subjects.
Comparison
Continuous measurement of brachial artery… vs Traditional calculation of flow-mediated…
Design
Cross-sectional
Authors
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Fixed-time FMD may underestimate endothelial function in older adults; leaves open whether continuous protocols improve risk prediction.
Cross-Sectional (n=36)
Does continuous measurement of flow-mediated dilatation (FMD) improve the accuracy of endothelial function assessment compared to traditional fixed-time measurement in young and older subjects?
Absolute Event Rate: 5.2% vs 7.8%
p-value: p=<0.05
Continuous measurement of flow-mediated dilatation is necessary because peak dilation times vary significantly with age and fitness, making traditional fixed-time measurements inaccurate.
Black et al. (2007) conducted a cross-sectional in Endothelial function (n=36). Older age and sedentary lifestyle vs. Young healthy subjects was evaluated on Flow-mediated dilatation (FMD) (p=<0.05). Flow-mediated dilatation was significantly higher in young subjects (7.8%) than in sedentary older subjects (5.2%, P<0.05), and time to peak diameter was significantly longer in older groups.
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