Key result
Standard two-dimensional cell culture systems induce a phenotype switch in cardiac fibroblasts to myofibroblasts, complicating the direct investigation of heterocellular crosstalk.
Population
Cardiac fibroblasts and cardiomyocytes in cell culture systems
Design
Review
Authors
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2D culture data warrant cautious interpretation for cardiac pathophysiology; leaves open validation of phenotype-preserving models for accurate heterocellular studies.
Standard 2D cell culture systems induce a phenotype switch in cardiac fibroblasts to myofibroblasts, highlighting the need for new methodologies to study true fibroblast-cardiomyocyte interactions.
Stephan Rohr (2011) reported a review. Standard two-dimensional cell culture systems induce a phenotype switch in cardiac fibroblasts to myofibroblasts, complicating the direct investigation of heterocellular crosstalk.
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