A Triglyceride-Glucose Index cutoff of 9.34 identified left ventricular diastolic dysfunction in asymptomatic type 2 diabetes patients with 80% sensitivity, 63% specificity, and an AUROC of 0.734.
Cross-Sectional (n=274)
Does the Triglyceride-Glucose Index (TGI) accurately identify subclinical HFpEF (LVDD) in asymptomatic patients with type 2 diabetes mellitus?
The Triglyceride-Glucose Index demonstrates fair diagnostic accuracy for identifying subclinical HFpEF in asymptomatic patients with type 2 diabetes, offering a simple and cost-effective screening tool.
Effect estimate: AUROC 0.734
p-value: p=<0.001
A BSTRACT Context: Diabetic cardiomyopathy is an entity with a multifactorial pathophysiology, in which insulin resistance plays a key role. It increases the risk of heart failure with preserved ejection fraction (HFpEF) in type 2 diabetes mellitus (T2DM). The Triglyceride-Glucose Index (TGI) is a novel measure of insulin resistance which is simple to use and may serve as an accessible marker for subclinical HFpEF. Aims: To evaluate the association between TGI and subclinical HFpEF in asymptomatic patients with T2DM and assess its diagnostic performance. Methods: This was a cross-sectional observational analytic study in which 274 asymptomatic T2DM patients aged 18–60 years were enrolled. Patients with known cardiovascular disease, hypertension, macro- and microvascular complications, and other major comorbidities were excluded. TGI was calculated, and all participants underwent 2D echocardiography to assess left ventricular diastolic function. Results: LV diastolic dysfunction (LVDD) was detected in 62.4% of participants. TGI was significantly higher in patients with LVDD (mean 9.69 ± 0.49) versus those without (mean 9.23 ± 0.63), P < 0.001. ROC analysis identified a TGI cutoff of 9.34 as optimal for detecting LVDD, yielding a sensitivity of 80%, a specificity of 63%, and an AUROC of 0.734. To achieve high sensitivity (100%) and NPV (100%), the cutoff of 8.32 is best for screening for LVDD. Conclusions: TGI demonstrates fair diagnostic accuracy for identifying subclinical HFpEF in T2DM. Given its simplicity and cost-effectiveness, it may be considered a valuable screening tool in resource-limited settings.
Routhu et al. (Fri,) conducted a cross-sectional in type 2 diabetes mellitus (n=274). Triglyceride-Glucose Index (TGI) was evaluated on Left ventricular diastolic dysfunction (LVDD) (AUROC 0.734, p=<0.001). A Triglyceride-Glucose Index cutoff of 9.34 identified left ventricular diastolic dysfunction in asymptomatic type 2 diabetes patients with 80% sensitivity, 63% specificity, and an AUROC of 0.734.