Key result
A subdepressor dose of candesartan reduced pressure overload-induced transient reactive oxygen species production, perivascular inflammation, and subsequent myocardial fibrosis in a rat model of aortic constriction.
Why the study?
Does candesartan reduce reactive oxygen species production, perivascular inflammation, and cardiac fibrosis in a rat model of pressure overload?
Population
Male Wistar rats (300-400 g) subjected to suprarenal aortic constriction (AC) or sham operation.
Comparison
Candesartan 0.1 mg/kg/day orally, starting 7… vs Vehicle.
Design
Preclinical, Rats were randomized to the following three groups., Each…
Follow-up
14 days
Authors
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Cautions against clinical extrapolation from rodent data; leaves open BP-independent anti-fibrotic mechanisms for future human studies.
Does candesartan reduce reactive oxygen species production, perivascular inflammation, and cardiac fibrosis in a rat model of pressure overload?
In a rat model of pressure overload, candesartan prevented myocardial fibrosis by reducing transient vascular reactive oxygen species production and early perivascular inflammation, independent of its blood pressure-lowering effect.
Kai et al. (2006) studied Pressure overload-induced cardiac remodeling. Candesartan vs. Vehicle was evaluated on Reactive oxygen species production, perivascular inflammation, and myocardial fibrosis. A subdepressor dose of candesartan reduced pressure overload-induced transient reactive oxygen species production, perivascular inflammation, and subsequent myocardial fibrosis in a rat model of aortic constriction.
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