Key result
Severely elevated RVSP linked to ~92% greater risk of HF hospitalization or mortality.
Why the study?
Although right ventricular systolic pressure is associated with adverse outcomes in heart failure, the clinical importance of serial measurements has not been studied.
Does right ventricular systolic pressure (RVSP) trajectory predict hospitalization and mortality in patients with chronic heart failure?
Population
4319 patients with HF and 2 echocardiograms performed ≥ 6 months apart
Comparison
RVSP severity categories and change in RVSP categories between echocardiograms
Design
Cohort study
Follow-up
Median 19.4 months
Authors
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Serial RVSP monitoring may refine HF risk stratification; leaves open whether it should guide therapy.
Cohort (n=4,319)
Yes
Does right ventricular systolic pressure (RVSP) trajectory predict hospitalization and mortality in patients with chronic heart failure?
Hazard Ratio: 1.92 (95% CI 1.6–2.31)
p-value: p=<0.001
Both elevated baseline RVSP and an improving RVSP trajectory are associated with increased risk of heart failure hospitalization and all-cause mortality in patients with chronic heart failure.
Kotrri et al. (2023) conducted a cohort in Chronic Heart Failure (n=4,319). Elevated right ventricular systolic pressure (RVSP) and RVSP trajectory vs. Normal right ventricular systolic pressure (< 40 mm Hg) was evaluated on Time to heart failure hospitalization or all-cause mortality (HR 1.92, 95% CI 1.60-2.31, p=<0.001). Severely elevated right ventricular systolic pressure (HR 1.92) and improving pressure trajectory (HR 1.16) were independently associated with an increased risk of heart failure hospitalization or mortality.
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