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April 9, 2020CJC OpenOpen Access

Evaluation of the Impact of an Echocardiographic Diagnosis of Pulmonary Hypertension on Patient Outcomes

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Key result

Elevated RVSP ≥ 30 mm Hg was common and associated with significantly higher Charlson Comorbidity Index and prior hospitalizations compared to RVSP < 30 mm Hg (P<0.0001).

Why the study?

Elevated RVSP on routine echocardiography is common but underappreciated, and recent changes lowering the hemodynamic threshold for PH further cloud its clinical significance.

Does elevated right ventricular systolic pressure on echocardiography correlate with increased comorbidities and hospitalizations in patients undergoing routine echocardiography?

Population

9291 unique patients undergoing transthoracic echocardiography in Ontario, Canada

Comparison

RVSP strata (< 30 vs 30 to < 40 vs ≥ 40 mm Hg)

Design

Retrospective cohort study

Authors

PXPing Yu XiongThe Central Hospital of Enshi Tujia and Miao Autonomous PrefectureZJZardasht JaffQueen's UniversityCDChristine L. D’ArsignyQueen's University

Discussion

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Member takes

Implication

Elevated RVSP on routine echo may warrant closer monitoring; leaves open whether the updated PH threshold refines risk stratification in observational data.

Study Design

Type

Cohort (n=9,291)

Multicenter

No

Structured PICO

Does elevated right ventricular systolic pressure on echocardiography correlate with increased comorbidities and hospitalizations in patients undergoing routine echocardiography?

P
Population
9,291 patients who underwent transthoracic echocardiography at a single center in Ontario, Canada, between 2013 and 2016.
E
Exposure
Elevated right ventricular systolic pressure (RVSP) ≥ 30 mm Hg on echocardiography
C
Comparator
Normal right ventricular systolic pressure (RVSP) < 30 mm Hg on echocardiography
O
Outcome
Charlson Comorbidity Index (CCI) and number of hospitalizations 1 year before the echocardiography

Main Result

p-value: p=< 0.0001

Elevated RVSP ≥ 30 mm Hg on routine echocardiography is common and associated with higher comorbidity and hospitalization rates, yet is frequently underdiagnosed as pulmonary hypertension.

Cite This Study

Xiong et al. (2020) conducted a cohort in Elevated right ventricular systolic pressure / Pulmonary hypertension (n=9,291). Elevated right ventricular systolic pressure (RVSP ≥ 30 mm Hg) vs. RVSP < 30 mm Hg was evaluated on Charlson Comorbidity Index (CCI) and number of hospitalizations 1 year before echocardiography (p=< 0.0001). Elevated RVSP ≥ 30 mm Hg was common and associated with significantly higher Charlson Comorbidity Index and prior hospitalizations compared to RVSP < 30 mm Hg (P<0.0001).

synapsesocial.com/papers/6a964abf37dc33ab6afbac48https://doi.org/10.1016/j.cjco.2020.04.001
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Estimating pulmonary artery pressures by echocardiography in patients with emphysema2007 · 218 citations
  2. 2Echocardiography in the assessment of right heart function2007 · 177 citations
  3. 3Tricuspid Annular Displacement Predicts Survival in Pulmonary Hypertension2006 · 1,095 citations
  4. 4Threshold of Pulmonary Hypertension Associated With Increased Mortality2019 · 134 citations
  5. 5Clinical Profile and Underdiagnosis of Pulmonary Hypertension in US Veteran Patients2013 · 68 citations