Key result
Each 5 mmHg increase in RVSP is linked to ~6% higher mortality in HF.
Why the study?
Does increasing severity of pulmonary hypertension predict all-cause mortality in patients with heart failure?
Population
1612 patients with LVSD and symptomatic heart failure in Tayside, Scotland
Comparison
Increasing severity of pulmonary hypertension measured by RVSP in 5 mmHg increments
Design
Retrospective cohort study using linked echocardiogram and health data
Follow-up
Mean 2.8 ± 2.5 years
Authors
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Higher RVSP associated with mortality in HF with LVSD; leaves open whether PH severity informs risk stratification or trials.
Cohort (n=1,612)
Does increasing severity of pulmonary hypertension predict all-cause mortality in patients with heart failure?
Hazard Ratio: 1.06 (95% CI 1.03–1.08)
p-value: p=< 0.001
In patients with heart failure and left ventricular systolic dysfunction, each 5 mmHg increase in right ventricular systolic pressure is associated with a 6% increased risk of all-cause mortality.
Szwejkowski et al. (2011) conducted a cohort in Heart failure with left ventricular systolic dysfunction (n=1,612). Right ventricular systolic pressure (RVSP) was evaluated on All-cause mortality (HR 1.06, 95% CI 1.03-1.08, p=< 0.001). Each 5 mmHg increase in right ventricular systolic pressure was associated with a higher risk of all-cause mortality in patients with heart failure (HR 1.06; 95% CI 1.03-1.08; P<0.001).
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