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June 20, 2026Cancer BioscienceOpen Access

Metabolic Fuel, Molecular Code: How Cancer Rewires Metabolite-Driven Post-Translational Modifications to Shape Tumor Fate

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Authors

YWYutong WangCLChengxi LiBLBing Liu

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Overview

Review explores metabolic-PTM relationship in cancer, suggesting new therapeutic avenues for personalized medicine.

Key Points

  • This review investigates the role of metabolic reprogramming in regulating post-translational modifications (PTMs) in cancer.
  • Systematic exploration of metabolic pathways (glycolysis, lipid metabolism, TCA cycle) and their influence on PTMs.
  • Analysis of how PTMs affect oncoproteins and contribute to cancer traits like immune evasion and cell survival.
  • Evaluation of emerging therapies targeting metabolic pathways and PTM enzymes.
  • Dysregulated metabolism increases various PTMs, such as acetylation and palmitoylation, impacting key oncoproteins.
  • PTMs are intricately linked to critical cancer hallmarks, including ferroptosis resistance and immune evasion.
  • Potential therapies include metabolic substrate restriction and PTM enzyme modulation, pointing towards personalized medicine approaches.

Cite This Study

Wang et al. (2026) studied this question.

synapsesocial.com/papers/6a362de1db0793dc1a535f03https://doi.org/10.1016/j.cbs.2026.100005
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Also Consider

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  1. 1Post-translational modifications in metabolic reprogramming: implications for metabolic therapy and immunotherapy in cancer2026
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  3. 3Metabolism in Tumor: Mechanisms and Therapeutic Perspectives2026
  4. 4Editorial: Targeted cancer therapy through metabolic pathways2026
  5. 5Cancer Metabolism and Its Historical & Molecular Foundations: An Overview2026 · 4 citations