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Chronic pain, particularly nociplastic pain, is a common challenge in outpatient practice. Pain reprocessing therapy (PRT) is a therapeutic approach aimed at modifying the brain's interpretation of pain and breaking the fear-pain cycle. Drawing from theories and research on neuroplasticity and central sensitization, PRT proposes reframing symptoms as potentially harmless signals. Recent randomized controlled trials, including one with long-term follow-up, show a significant and sustained reduction in pain. This article summarizes the current research, conceptual foundations, available training programs, therapeutic techniques, and integration of PRT into practice, with an example from the clinical practice at the CHUV.
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Grabherr et al. (2026) studied this question.
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