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June 21, 2026International Journal of Medical SciencesOpen Access

Exploratory Immunophenotyping of Programmed cell death-1 (PD-1) Expression and Regulatory T-Cell (Treg) Profiles in Systemic Lupus Erythematosus and Healthy Controls: A Cohort Study with Illustrative Clinical Cases

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Authors

PHPo-Jen HsiaoJLJeng‐Wei LuYHYi-Jung Ho

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Overview

Cohort study explores PD-1 expression and Treg profiles in systemic lupus erythematosus, highlighting differences from healthy controls.

Key Points

  • The study aims to explore PD-1 expression and Treg profiles in patients with systemic lupus erythematosus compared to healthy controls.
  • Conducted a cohort study comparing PD-1 expression and Treg profiles between patients with systemic lupus erythematosus and healthy controls.
  • Utilized immunophenotyping techniques to assess cell profiles.
  • Included illustrative clinical cases to highlight findings.
  • Higher PD-1 expression observed in Treg cells from patients with systemic lupus erythematosus.
  • Altered Treg profiles identified, indicating potential dysregulation in immune response.
  • Findings suggest that changes in PD-1 and Treg profiles may contribute to disease pathology.

Cite This Study

Hsiao et al. (2026) studied this question.

synapsesocial.com/papers/6a377edf24f042ddf4c59ce0https://doi.org/10.7150/ijms.131673
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Increased percentages of PD-1 on CD4+T cells is associated with higher INF-γ production and altered IL-17 production in patients with systemic lupus erythematosus2014 · 35 citations
  2. 2PD-1 expressing B cells are expanded in lupus 44522025
  3. 3PD-1 deficiency reshapes the TCRβ repertoire and T-cell developmental programs associated with susceptibility to lupus-like autoimmunity2026
  4. 4POS1066 SINGLE-CELL MULTI-OMIC EVALUATION OF DIFFERENCES IN T CELL POPULATIONS IN PROGRESSION OF SLE2024
  5. 5Exploring the Role of PD-1 in the Autoimmune Response: Insights into Its Implication in Systemic Lupus Erythematosus2024 · 2 citations