Predictive efficiency of serum fibrinogen and D-Dimer levels for left ventricular remodelling after acute myocardial infarction

OBJECTIVE: We aimed to explore serum D-dimer plus fibrinogen (FIB) levels in acute myocardial infarction (AMI) for their efficiency in predicting subsequent left ventricular remodelling (LVRM). METHODS: With the period between September 2021 and January 2023 selected, 112 AMI patients hospitalised for treatment were enrolled as the subjects that were allocated to either the non-LVRM group (n = 76) or the LVRM group (n = 36) based on the findings of echocardiography. RESULTS: LVRM was found in 36 out of the 112 AMI patients, with an incidence rate of 32.14%, whereas the remaining 76 patients did not develop LVRM, accounting for 67.86%. The LVRM-related risk factors in AMI subjects included large infarction size, high D-dimer level, history of diabetes mellitus plus hypertension, infarction location (apex of left ventricle), and high FIB level (odds ratio > 1, p < 0.05). FIB and D-dimer levels had the areas under the plotted receiver operating characteristic curves for predicting LVRM in AMI patients of 0.764 and 0.875, respectively, showing high predictive values. FIB and D-dimer levels had a certain value in predicting LVRM in AMI patients within the threshold range of 0.04-0.95. CONCLUSION: The D-dimer and FIB level measurement for AMI sufferers is conducive to the prediction of LVRM incidence.