Key result
D-dimer-to-fibrinogen ratio was independently associated with in-hospital death in patients with acute myocardial infarction (HR 2.207; 95% CI 1.050-4.640; p=0.037).
Why the study?
Myocardial infarction carries high in-hospital mortality without aggressive clinical treatment, prompting evaluation of the prognostic worth of the D-dimer-to-fibrinogen ratio in acute myocardial infarction.
Does the D-dimer-to-fibrinogen ratio predict in-hospital death in patients with acute myocardial infarction?
Observational (n=133)
No
Does the D-dimer-to-fibrinogen ratio predict in-hospital death in patients with acute myocardial infarction?
Hazard Ratio: 2.207 (95% CI 1.05–4.64)
p-value: p=0.037
The D-dimer-to-fibrinogen ratio may serve as a useful independent predictor of in-hospital mortality in patients presenting with acute myocardial infarction.
Supports DFR as a prognostic marker in AMI; hypothesis-generating and requires prospective validation before clinical use.
Objective Myocardial infarction is a severe disease with high in-hospital mortality without aggressive clinical treatment. The study aims to evaluate prognostic worth of D-dimer-to-fibrinogen (FIB) ratio (DFR) for patients with acute myocardial infarction (AMI). Methods 133 patients (65 (37, 93) years old) from our hospital (China) with AMI were enlisted from January 2017 to December 2019. Patients were assigned into the survivor and nonsurvivor group based on in-hospital outcomes. Receiver operating characteristics (ROC) and multivariate analysis were fulfilled to analyze the prognostic value of DFR. Results The degree of DFR in the nonsurvivor group was significantly higher than that in the survivor group ( p < 0.05). Logistic regression analysis presented that DFR (hazard ratio (HR), 2.207; 95% confidence interval (CI), 1.050–4.640; p = 0.037) was independently related with in-hospital death. ROC demonstrated that the area under the curve (AUC) of DFR was = 0.808 (0.725–0.892) (sensitivity, 85.3%; specificity, 69.7%). Conclusion DFR might be a new independent predictor of in-hospital death for AMI patients. Further studies are needed to validate this preliminary finding.
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Zhang et al. (2022) conducted an observational in Acute myocardial infarction (n=133). D-dimer-to-fibrinogen ratio (DFR) was evaluated on In-hospital death (HR 2.207, 95% CI 1.050-4.640, p=0.037). D-dimer-to-fibrinogen ratio was independently associated with in-hospital death in patients with acute myocardial infarction (HR 2.207; 95% CI 1.050-4.640; p=0.037).
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