Key result
AltaValve atrial-fixation TMVR minimizes the risk of left ventricular outflow tract obstruction.
The AltaValve System is an atrial fixation TMVR designed to minimize the risk of LVOT obstruction in patients with narrow left ventricular outflow tracts.
Most TMVR technologies rely on sub-valvular anchoring using rigid mechanisms (e.g., barbs, tethers, paddles), which interfere with the natural physiology of the mitral valve (MV) and annular dynamics increasing the risk of LVOT obstruction (LVOTO). The AltaValve™ System (4C Medical Technologies, Inc., Minneapolis, MN) is an atrial fixation TMVR designed to minimize risk for LVOTO.
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Basra et al. (2026) studied this question. The AltaValve System, an atrial fixation transcatheter mitral valve replacement, is designed to minimize the risk of left ventricular outflow tract obstruction.
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