Hypertension and 10-year risk of coronary artery diseases in adult population: Yazd healthy heart project.

Q: What is the clinical evidence from this study?

Study design: Cohort. Population: Coronary Artery Disease (CAD) (n=1553). Intervention: Hypertension vs. No hypertension. Primary outcome: Incidence of coronary artery disease (composite of fatal and nonfatal CAD, MI, PCI, CABG, and new angina pectoris) (HR 1.73, 95% CI 1.23-2.43, p=0.002).

Q: What does this research mean for the field?

Hypertension significantly increases the 10-year risk of coronary artery disease in adults. Novelty: ClaimNovelty.CONFIRMATORY. Consensus alignment: ConsensusAlignment.NEUTRAL.

Mohammadtaghi Sarebanhassanabadi; Mahdieh Mousavirad; Lida Hosseini; Pedro Marques-Vidal; A M Kraemer; Seyedeh Mahdieh Namayandeh; Hamideh Mihanpour; Sima Mozafari

doi:10.48305/arya.2025.45949.3127

January 1, 2026

Hypertension and 10-year risk of coronary artery diseases in adult population: Yazd healthy heart project.

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Key result

Hypertension is linked to ~73% higher 10-year risk of coronary artery disease.

HR 1.73
95% CI 1.23-2.43
P=0.002
n=1,553

Figures

Why the study?

Although the association between hypertension and CAD has been investigated in Western countries, limited research has been conducted in Asia and the Middle East.

Does hypertension increase the 10-year risk of incident coronary artery disease in an adult Iranian population?

Key Points

To evaluate the association between baseline hypertension and the 10-year incidence of coronary artery disease in an adult cohort.
Recorded baseline demographic characteristics, anthropometric parameters, biochemical blood tests, and lifestyle data.
Assessed the association between hypertension and 10-year CAD incidence using multivariable Cox regression models.
Over 10 years of follow-up, CAD incidence was 14.5% overall (16.8% in men and 12.0% in women), developing in 25.27% of hypertensive individuals compared to 8.50% of nonhypertensive individuals.
Hypertension independently increased CAD risk in the overall sample (HR = 1.73; 95% CI: 1.23-2.43), in men (HR = 1.64; 95% CI: 1.09-2.46), and in women (HR = 2.16; 95% CI: 1.15-4.05; p for interaction ≥0.05).

Study Design

Type

Cohort (n=1,553)

Multicenter

No

Structured PICO

Does hypertension increase the 10-year risk of incident coronary artery disease in an adult Iranian population?

P

Population

1,553 adult participants aged 20-74 years without prior CAD were followed for approximately 10 years to assess the association between hypertension and incident coronary artery disease.

E

Exposure

Hypertension at baseline (defined as systolic blood pressure ≥ 140 mmHg, diastolic blood pressure ≥ 90 mmHg, or consumption of anti-hypertensive medication).

C

Comparator

No hypertension at baseline.

O

Outcome

Composite of fatal and nonfatal coronary artery disease (CAD), myocardial infarction (MI), percutaneous coronary intervention (PCI), coronary artery bypass grafting (CABG), and new angina pectoris over approximately 10 years of follow-up.composite

Main Result

Hazard Ratio: 1.73 (95% CI 1.23–2.43)

Absolute Event Rate: 25.27% vs 8.5%

p-value: p=0.002

Limitations

Did not account for potential confounding factors such as genetic predisposition, dietary habits, sleep patterns, and mental health status
Blood pressure was measured only at baseline and 10-year follow-up, which may have led to overestimation of hypertension prevalence and reduced relative risks
Did not distinguish between controlled and uncontrolled hypertension
19.87% loss to follow-up may have introduced attrition bias
Did not account for potential confounding factors such as genetic predisposition, dietary habits, sleep patterns, and mental health status.
Blood pressure was measured only at baseline and the 10-year follow-up, potentially leading to an overestimation of hypertension prevalence and reduction in relative risks.
Did not distinguish between individuals with controlled and uncontrolled hypertension.
19.87% loss to follow-up, which could introduce attrition bias.

Implication

Hypertension independently increases the 10-year risk of developing coronary artery disease by 73% in an adult Iranian population, emphasizing the critical need for regional blood pressure screening and management.

Abstract

BACKGROUND: The incidence of coronary artery disease (CAD) is influenced by several risk factors, including hypertension. Although the association between hypertension and CAD has been investigated in Western countries, limited research has been conducted in Asia and the Middle East. We investigated the association between hypertension and the 10year risk of CAD in the adult population. METHODS: In this cohort study, 2,000 participants aged 20 to 74 years in the Yazd Healthy Heart Project were enrolled in 2005-2006 and followed up to 2015-2016. Participants with a history of CAD were excluded. At baseline, data on demographic characteristics, anthropometric measurements, biochemical blood tests, and lifestyle factors were collected. The association between hypertension and approximately 10year CAD risk was assessed using the Cox regression model. RESULTS: The baseline prevalence of hypertension among adults was 36.1%. During the tenyear followup, CAD incidence was 16.8% in men, 12.0% in women, and 14.5% in the total population. After adjusting for potential confounders, hypertension increased the risk of CAD in men (HR = 1.64; 95% CI: 1.09-2.46), women (HR = 2.16; 95% CI: 1.15-4.05), and the whole sample (HR = 1.73; 95% CI: 1.23-2.43). This association was similar in men and women (p for interaction ≥0.05). CONCLUSION: This study demonstrated a significant association between hypertension and CAD risk, highlighting the need for targeted interventions in populations with hypertension to reduce CAD risk.

Discussion

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Cite This Study

Sarebanhassanabadi et al. (2026) conducted a cohort in Coronary Artery Disease (CAD) (n=1,553). Hypertension vs. No hypertension was evaluated on Incidence of coronary artery disease (composite of fatal and nonfatal CAD, MI, PCI, CABG, and new angina pectoris) (HR 1.73, 95% CI 1.23-2.43, p=0.002). Hypertension was independently associated with a 73% increased 10-year risk of developing coronary artery disease (HR 1.73) compared to normotensive individuals.

synapsesocial.com/papers/6a3d91bf408ebb922448b10b https://doi.org/10.48305/arya.2025.45949.3127

Topics

Hypertension management

Coronary artery disease

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Hypertension and 10-year risk of coronary artery diseases in adult population: Yazd healthy heart project.

Figures

Key Points

Study Design

Structured PICO

Main Result

Limitations

Implication

Abstract

Discussion

Cite This Study

Topics

Hypertension and 10-year risk of coronary artery diseases in adult population: Yazd healthy heart project.

Figures

Key Points

Study Design

Structured PICO

Main Result

Limitations

Implication

Abstract

Discussion

Cite This Study

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